Thursday, January 5, 2012

IRL: Logitech Y-R0026 Bluetooth keyboard, Apple MacBook and a Virgin America flight with the Series 5 Chromebook

Welcome to IRL, an ongoing feature where we talk about the gadgets, apps and toys we're using in real life and take a second look at products that already got the formal review treatment.

In this, the last IRL until after we get back from CES, we've got a tale from Brian, who spent his Virgin America flight home to the west coast playing with his first Chromebook. Meanwhile, Andy defends the idea of spending $130 on a Bluetooth keyboard, and Mr. Christopher Trout explains why he's loathe to recycle his three year-old MacBook, even if it has devolved into a glorified media hub. Before we turn around and give you wall-to-wall coverage of all the new stuff, meet us past the break to spend a few minutes with some oldies-but-goodies.

Continue reading IRL: Logitech Y-R0026 Bluetooth keyboard, Apple MacBook and a Virgin America flight with the Series 5 Chromebook

IRL: Logitech Y-R0026 Bluetooth keyboard, Apple MacBook and a Virgin America flight with the Series 5 Chromebook originally appeared on Engadget on Wed, 04 Jan 2012 14:00:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/01/04/irl-logitech-y-r0026-bluetooth-keyboard-apple-macbook-and-a-vi/

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Wednesday, January 4, 2012

Hydrogen sulfide reduces glucose-induced injury in kidney cells

ScienceDaily (Jan. 3, 2012) ? Hydrogen sulfide, a gas notorious for its rotten-egg smell, may have redeeming qualities after all. It reduces high glucose-induced production of scarring proteins in kidney cells, researchers from The University of Texas Health Science Center San Antonio report in the Journal of Biological Chemistry.

The paper is scheduled for print publication in early 2012.

"There is interest in gases being mediators of biological events," said B.S. Kasinath, M.D., professor of medicine and a nephrologist with UT Medicine San Antonio, the clinical practice of the School of Medicine at the UT Health Science Center. "We found that when we added sodium hydrosulfide, a substance that releases hydrogen sulfide, to kidney cells exposed to high glucose, it decreased the manufacture of matrix proteins that scar the kidney." Consistent with this finding, enzymes in the kidney that facilitate production of hydrogen sulfide were reduced in mice with type 1 or type 2 diabetes, Dr. Kasinath and his team reported.

Scarring in the kidney, called renal fibrosis, is a core defect leading to end-stage kidney disease. Nearly half of end-stage kidney disease in the U.S. is related to diabetes, which is a disease marked by poor regulation of blood glucose.

"We have found a way to decrease matrix protein synthesis, which is a problem in diabetes," Dr. Kasinath said. Because the studies are limited to cells, the finding should not be extrapolated to the treatment of human diabetic kidney disease, he emphasized.

The finding paves the way for studies in mice or other animal models. Both the safety and effectiveness of hydrogen sulfide should be established in animal models of kidney disease before human trials can be considered. This precaution is required because hydrogen sulfide, at higher concentrations, is known to be a toxic agent.

Journal of Biological Chemistry editors selected the team's manuscript to be the Paper of the Week, reserved for the top 1 percent of manuscripts in significance and overall importance. About 50 to 100 papers are selected for this recognition from the more than 6,600 the journal publishes each year.

Hak Joo Lee, Ph.D., a postdoctoral fellow in the Division of Nephrology, is the lead author on the study. Dr. Kasinath, also a member of the Barshop Institute for Longevity and Aging Studies at the Health Science Center, is the senior author and wishes to acknowledge the contributions of his co-authors.

This work was supported by a grant from the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases, (DK077295), and a U.S. Department of Veterans Affairs research grant to Dr. Kasinath, the principal investigator.

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The above story is reprinted from materials provided by University of Texas Health Science Center at San Antonio.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. H. J. Lee, M. M. Mariappan, D. Feliers, R. C. Cavaglieri, K. Sataranatarajan, H. E. Abboud, G. Ghosh Choudhury, B. S. Kasinath. Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. Journal of Biological Chemistry, 2011; DOI: 10.1074/jbc.M111.278325

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/gDsbv1D-Zeg/120103165039.htm

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Tuesday, January 3, 2012

Yemenis rally, demand president face trial

Yemeni soldiers and officers march during a rally demanding reforms and dismissal of a senior official over alleged corruption in Taiz, Yemen, Saturday, Dec. 31, 2011. Arabic on the banners, center, reads, "take from me the rifle and give me the civil state," and at right, "with our standing against corruption, we will build army to protect the country." The son of Yemen's outgoing president is leading a crackdown to purge the Republican Guard, which he commands, of any rebellious officers found to be siding with anti-government protesters, a military official said Saturday. (AP Photo/Anees Mahyoub)

Yemeni soldiers and officers march during a rally demanding reforms and dismissal of a senior official over alleged corruption in Taiz, Yemen, Saturday, Dec. 31, 2011. Arabic on the banners, center, reads, "take from me the rifle and give me the civil state," and at right, "with our standing against corruption, we will build army to protect the country." The son of Yemen's outgoing president is leading a crackdown to purge the Republican Guard, which he commands, of any rebellious officers found to be siding with anti-government protesters, a military official said Saturday. (AP Photo/Anees Mahyoub)

A relative of a protester who was killed in recent clashes with security forces chants prayers next to his grave following a demonstration demanding the prosecution of Yemen's President Ali Abdullah Saleh in Sanaa, Yemen, Friday, Dec. 30, 2011. Tens of thousands are demonstrating in Yemen, demanding that their longtime president be put on trial for the killing of hundreds of unarmed protesters since pro-democracy protests began 10 months ago. (AP Photo/Hani Mohammed)

(AP) ? Yemen's opposition on Sunday accused outgoing President Ali Abdullah Saleh of trying to torpedo a power transfer deal by sparking a new crisis, as troops loyal to him clashed with opposition forces, killing three.

The violence was evidence that the president's signature on a power transfer deal has not ended months of turmoil that have benefited al-Qaida-linked militants.

Sunday's clashes followed Saleh's decision not to leave the country, a move likely to embolden his relatives, who control key security posts.

His opponents demand the removal of all of Saleh's relatives from top security positions. Huge crowds of protesters have called for Saleh himself to be put on trial for the killing of hundreds of protesters, though the power transfer deal gives him immunity from prosecution.

Vice President Abed Rabbo Mansour Hadi told his new national unity government on Sunday, in their first official session, that the power transfer agreement, engineered by Yemen's powerful Gulf Arab neighbors, must be implemented soon.

"We need to move vigorously and effectively to implement the Gulf initiative and its mechanisms," he said.

The new government's first task is to push through the law shielding Saleh from prosecution for alleged corruption and for violence against protesters. Saleh made that a condition for signing the deal to relinquish power after 33 years of rule over the Arab world's poorest nation.

Yet more than a month after Saleh signed, and after the possibility of his flying to the U.S. was raised, Saleh is still in Yemen, still wielding significant power and showing few, if any, signs of giving in.

Ten months of mass protests and armed clashes between forces loyal to Saleh and his opponents, including army units that followed powerful tribal leaders siding with the opposition, have left a power vacuum. The Yemen branch of al-Qaida, considered one of the world's most dangerous, has taken advantage of that to dig in to positions in the country's south, taking over towns and villages.

Yemen's military fights frequent battles with the Islamist militants but has failed to dislodge them.

In the latest skirmish between Saleh backers and opponents, anti-government tribesmen in el-Fardha Nehem region, about 50 miles (80 kilometers) northeast of the capital Sanaa, said two people were killed and two others wounded when Saleh's Republican Guards, led by his son, shelled their homes.

Opposition spokesman Mohamed Sabri accused Saleh of undercutting security as a way of arguing that he must stay in power.

"This man does not respect his commitments with others," Sabri said. "Saleh is creating a new crisis."

In the capital, a civilian bystander was killed when Republican Guard troops clashed with supporters of tribal chief Sadeq al-Ahmar, who was once a regime ally, but defected to the opposition in March, activists said.

Supporters of al-Ahmar and Saleh's troops exchanged fire in Sanaa's northern district of Hassaba, according to a security official and witnesses, resulting in the death of the bystander. The official spoke on condition of anonymity because he was not authorized to release the information.

The fighting Sunday ended after the vice president held talks with both sides. He was also able to quell violence in el-Fardha Nehem region.

Large crowds of Yemenis rallied in major cities Sunday, demanding the outgoing president be put on trial for the deaths of protesters.

The U.N. estimates that hundreds of protesters have been killed and thousands wounded since last February, when anti-government protests erupted across major cities.

Tens of thousands marched in the streets of Sanaa, chanting that Saleh "must stand before a judge." Another large crowd of marchers echoed the chant in Taiz, Yemen's second largest city.

Activist Fathi al-Hamadi said the "only place for Saleh to go to is the court dock."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-01-01-Yemen/id-341b65d3cda14aacb78e2eb6e60c0671

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How to Get Unlimited Data on Verizon Right Now [How To]

Verizon notoriously killed its unlimited data plans this past summer, leaving users with only tiered options with ugly data caps. Not cool. But such is life in the era of bandwidth slurping smartphone ubiquity. Or is it? Apparently there's a secret hack that lets Verizon users add unlimited data to their plans. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/yEYGISYKoSM/how-to-get-unlimited-data-on-verizon-right-now

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End of the Year Prediction Thread (Little green footballs)

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